March 21st 2017


Leiden University

Leiden Academic Centre for Drug Research (LACDR)

Medicinal Chemistry, Einsteinweg 55

2333 CC, Leiden, Telephone: +31 6 19010 038

Email: gerard@gjpvanwesten.nl

Keywords: computational chemist, modeling, polypharmacology, big data  

scientific presenting, scientific writing, linux administration

Scientific and personal interests

·       Predictive polypharmacology, cheminformatics, bioinformatics, text mining, interdisciplinary research, big data, high performance / GPU computing, visualization

·       Computer geek (likes tinkering with hardware and networks), ZFS, open fire cooking, likes driving / road tripping

Skill set

·       Statistical modeling, big data analysis, visualization & dimensionality reduction, workflow tools, scripting in several languages, structure based modeling, SQL, high performance computing

Scientific Publications

·       36 Articles in peer-reviewed international journals (h-index 18, average impact factor 8, average citations per paper 28), multiple talks and poster presentations at scientific meetings (see www.gjpvanwesten.nl).

 

Current Positions

·       Assistant Professor (Tenure Track, Drug & Target Discovery Cluster)                       10/2016 Present

o   Computational Chemical Biology

·       Founder of Getuyg Data Analytics                                                                                           07/2015 – Present

o   Data science and storage consultancy

Previous Positions

·       Senior Postdoc Medicinal Chemistry (LACDR)                                                                   05/2015 09/2016

o   Fellowship at Science Faculty (LACDR & LIACS)

·       Senior Postdoc ChEMBL group                                                                                                11/2013 05/2015

o   EMBL Interdisciplinary POstDoc (EIPOD) fellowship             

·       Guest Scientist Leiden University (LACDR)                                                                         09/2014 05/2015

·       Guest Scientist University of Cambridge                                                                              08/2014 08/2014

·       Guest Lecturer University of Strathclyde (Glasgow)                                                        12/2013 12/2014

·       Postdoctoral fellow ChEMBL group                                                                                       05/2012 11/2013

o   EMBL Interdisciplinary POstDoc (EIPOD) fellowship

 

Grants and Awards

Notes

Amount

Year of award

IWT Research Grant (co-lead)

Supports 2 year postdoc

€200,000

2016

Industry Collaboration (Unilever)

 

€100,000

2015

NWO Veni Personal Grant

Reviewed 3 times A+

€250,000

2015

Marie Curie (COFUND) / EMBL Interdisciplinary POstDoc (EIPOD)

30 / 400 applications granted

€125,000

2011

Personal Ph.D. grant sponsored by Janssen Pharmaceutica

Based on results from internship

€300,000

2007

Best presentation EBI Postdoc day

All postdocs presented

€130

2014

‘Discoverer of the year 2013’

Best PhD thesis Science faculty

€2,500

2014

Best presentation in the Pharmacochemistry session (FIGON Days)

€400

2011

Best presentation TIPharma GPCR Forum

€100

2011

Bronze prize, national Ph.D. student competition (FIGON Days)

€750

2010

Silver Prize KNCV Pharmacochemistry

€150

2010

1st prize LACDR Ph.D. student competition

€50

2010


Consultancy work

·       CULGI (chemical modeling company, Leiden, Netherlands)

·       Stage Pharma (biotech startup, Utrecht, Netherlands)

o   Generation of polypharmacological predictive models (aminergic GPCRs)

·       Johnson & Johnson Pharmaceuticals (Beerse, Belgium)

o   Predictive polypharmacological models in discovery

 

Education

·       Ph.D. in Proteochemometrics (polypharmacology modeling)                                        11/2007 01/2013

Leiden Academic Center for Drug Research (Leiden University, The Netherlands)

o   Predictive computational models using ligand and protein similarity simultaneously (Proteochemometrics, Ph.D. position was funded by Janssen Pharmaceutica (Johnson and Johnson Pharmaceuticals)

 

·       M.Sc. Bio-Pharmaceutical Sciences                                                                                         09/2001 09/2007 

Leiden University (Leiden, The Netherlands) with the following research projects:

o   Characterizing the inhibition of P-Selectin by GA-GWVDV (36 weeks, molecular biology; department of Bio-Pharmaceutics of the LACDR)

 

o   Characterizing HIV-1 Reverse Transcriptase Non-Nucleoside Reverse Transcriptase Inhibitor Resistance (24 weeks, chem-informatics, department of Chem-informatics and Modeling of Tibotec / Janssen Pharmaceutica Belgium)

 

Supervision and Teaching

·       Chem and Bioinformatics in Computational biomedical and drug research.

·       Portfolio assignment in Design and Synthesis.

·       Cheminformatics in Minor Modern Drug Discovery.

·       Designed practical course Computational Drug Design, 10-day course on the fundamentals of computational drug design (given twice to 20 students).

·       Supervision of 2 Postdocs, 2 PhD Student, > 10 M.Sc. students, and > 10 B.Sc. students

 

Reviewing Activities

·       Ad hoc referee for the following peer reviewed journals: ACS Medicinal Chemistry Letters. Bioinformatics, Journal of Structural Biology, Journal of Medicinal Chemistry, Journal of Chemical Information & Modeling, Journal of Cheminformatics, Molecular Informatics, Nature Methods

·       2015 EIPOD interviews (external expert)

 

Management & organization

       Served 1 year as postdoc representative at EBI. Duties included liaising between postdocs and EBI or EMBL faculty, feedback with regard to the training program, organizing symposia and lunch-meetings, inviting external speakers. 


       Member of organizing committee for EMBL postdoc retreat. Bi-annual 3 day event, 2 days scientific program and 1 afternoon of social program. Attended by approximately 80 international postdocs from EMBL outstations in Heidelberg, Grenoble, Hamburg, Hinxton, and Monterotondo. Additionally, the committee hosted a number of external speakers from academia, industry, and academic publishing. 


       Founder of Camball annual classic rally (2012 – Present)

       Crew at checkpoint Amsterdam for Gumball 3000 rally (2010 – 2015)

       Served a year on the Science Club committee, in charge of the faculty café that provides a venue for symposia, discussion, and hosting of weekly science faculty drinks on Thursday 


       Served a year as president of L.P.S.V. ,,Aesculapius” , student association [1]


[1]Was a member of various committees including: Dies Natalis Committee, Freshmen Weekend Committee, Yearbook Committee and Internet Committee during membership of the L.P.S.V. „Aesculapius”

Ċ
Gerard van Westen,
Feb 2, 2016, 1:02 AM
Ċ
Gerard van Westen,
Mar 21, 2017, 9:29 AM
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